Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 70 0.0 1.0 0.534 0.353
biological_process el 70 0.0 1.0 0.754 0.421
biological_process ka 70 0.0 1.0 0.843 0.364
biological_process node2vec 70 0.0 0.985 0.45 0.332
biological_process rf 70 0.0 1.0 0.757 0.416
cellular_component ct 71 0.0 0.992 0.166 0.242
cellular_component el 71 0.0 1.0 0.202 0.274
cellular_component ka 71 0.0 1.0 0.536 0.485
cellular_component rf 71 0.0 1.0 0.191 0.277
disease ct 25 0.0 0.916 0.209 0.249
disease el 25 0.0 1.0 0.521 0.498
disease ka 25 0.001 1.0 0.562 0.495
disease node2vec 25 0.0 0.965 0.411 0.408
disease rf 25 0.0 1.0 0.521 0.498
genetic_interaction_weighted ct 73 0.0 0.955 0.266 0.264
genetic_interaction_weighted el 73 0.0 1.0 0.341 0.323
genetic_interaction_weighted ka 73 0.003 1.0 0.891 0.31
genetic_interaction_weighted node2vec 73 0.0 0.984 0.337 0.314
genetic_interaction_weighted rf 73 0.0 1.0 0.339 0.323
molecular_function ct 71 0.0 0.998 0.208 0.348
molecular_function el 71 0.0 1.0 0.197 0.334
molecular_function ka 71 0.0 1.0 0.393 0.476
molecular_function rf 71 0.0 1.0 0.205 0.345
pathway ct 30 0.001 1.0 0.716 0.315
pathway el 30 0.001 1.0 0.601 0.489
pathway ka 30 0.001 1.0 0.701 0.456
pathway node2vec 30 0.0 0.983 0.325 0.331
pathway rf 30 0.001 1.0 0.601 0.489
phenotype ct 26 0.0 0.959 0.321 0.359
phenotype el 26 0.0 1.0 0.501 0.472
phenotype ka 26 0.001 1.0 0.693 0.461
phenotype node2vec 26 0.0 0.994 0.38 0.411
phenotype rf 26 0.0 1.0 0.5 0.474
protein_interaction ct 73 0.0 0.777 0.037 0.129
protein_interaction el 73 0.0 0.681 0.034 0.115
protein_interaction ka 73 0.001 1.0 0.347 0.472
protein_interaction node2vec 73 0.002 0.811 0.061 0.152
protein_interaction rf 73 0.0 0.647 0.033 0.109

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 73 0.0 1.0 0.246 0.334
integration_mean_by_presence el 73 0.0 0.707 0.033 0.113
integration_mean_by_presence ka 73 0.0 1.0 0.159 0.355
integration_mean_by_presence node2vec 73 0.0 0.988 0.197 0.27
integration_mean_by_presence rf 73 0.0 0.86 0.06 0.141
mean ct 73 0.0 1.0 0.239 0.34
mean el 73 0.0 0.677 0.029 0.1
mean ka 73 0.0 1.0 0.16 0.354
mean node2vec 73 0.0 0.883 0.143 0.214
mean rf 73 0.0 0.549 0.039 0.09

Backup Pairs Coverage By Layer

CDF plots of non integrated kernels

CDF plots of integrated kernels